staples peptide and patent restriction

US5567588A - Systematic evolution of ... - Google Patents- staples peptide and patent restriction ,US5567588A US08/461,069 US46106995A US5567588A US 5567588 A US5567588 A US 5567588A US 46106995 A US46106995 A US 46106995A US 5567588 A US5567588 A US 5567588A Authority US United States Prior art keywords nucleic acid nucleic acids primer extension affinity partitioning Prior art date 1990-06-11 Legal status (The legal status is an assumption and is not a legal conclusion.Gelatin - WikipediaGelatin or gelatine (from Latin: gelatus meaning "stiff" or "frozen") is a translucent, colorless, flavorless food ingredient, commonly derived from collagen taken from animal body parts. It is brittle when dry and gummy when moist. It may also be referred to as hydrolyzed collagen, collagen hydrolysate, gelatine hydrolysate, hydrolyzed gelatine, and collagen peptides after it has undergone ...



What can be patented? - Patent Topics | LegalZoom

Apr 13, 2012·For example, although you would not get the benefit of the earlier filing date, there is no restriction against filing a full patent application two years after filing a Provisional Application. Again, the invention must not have been disclosed in a publication or sold one year or more before a Non-Provisional Application is filed.

Practice advisory update summary: Patent foramen ovale and ...

May 19, 2020·Objective To update the 2016 American Academy of Neurology (AAN) practice advisory for patients with stroke and patent foramen ovale (PFO). Methods The guideline panel followed the AAN 2017 guideline development process to systematically review studies published through December 2017 and formulate recommendations. Major recommendations In patients being considered for PFO …

Protein Primary Structure

ProtScale. ProtScale allows you to compute and represent the profile produced by any amino acid scale on a selected protein.An amino acid scale is defined by a numerical value assigned to each type of amino acid. The most frequently used scales are the hydrophobicity or hydrophilicity scales and the secondary structure conformational parameters ...

METHOD OF PREPARING STAPLED PEPTIDES - patents.justia

Jul 31, 2018·Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix …

Introduction of All-Hydrocarbon i,i+3 Staples into α ...

Jun 07, 2010·The introduction of all-hydrocarbon i,i+3 staples into α-helical peptide scaffolds via ring-closing olefin metathesis (RCM) between two α-methyl,α-pentenylglycine residues incorporated at i and i+3 positions, which lie on the same face of the helix, has been investigated. The reactions were found to be highly dependent upon the side-chain stereochemistry of the amino acids undergoing …

Over 40 years in protein expression and purification – a ...

Over 40 years in protein expression and purification – a historical perspective. by Christopher H. Taron, Ph.D., James C. Samuelson, Ph.D., and Lydia Morrison, M.S., New England Biolabs, Inc. New England Biolabs ® (NEB ®) has been integrally involved in expressing and purifying proteins since the dawn of the recombinant DNA era in the 1970s ...

US6616686B2 - Surgical staples and methods for stapling ...

US6616686B2 US09/949,438 US94943801A US6616686B2 US 6616686 B2 US6616686 B2 US 6616686B2 US 94943801 A US94943801 A US 94943801A US 6616686 B2 US6616686 B2 US 6616686B2 Authority US United States Prior art keywords base staple surgical staple legs puncture Prior art date 2000-09-08 Legal status (The legal status is an assumption and is not a legal conclusion.

EPO - T 1252/13 (Collagen producing plants/COLLPLANT) of 5 ...

May 07, 2017·The restriction to "vacuole transit peptide" was also a selection from this disclosure. Co-sequestration of collagen chains and P4H as a goal was disclosed in the application as filed on page 3, third paragraph and page 15, fourth paragraph, but it was not disclosed that collagen and P4H had to have the same kind of modifications.

US6616686B2 - Surgical staples and methods for stapling ...

US6616686B2 US09/949,438 US94943801A US6616686B2 US 6616686 B2 US6616686 B2 US 6616686B2 US 94943801 A US94943801 A US 94943801A US 6616686 B2 US6616686 B2 US 6616686B2 Authority US United States Prior art keywords base staple surgical staple legs puncture Prior art date 2000-09-08 Legal status (The legal status is an assumption and is not a legal conclusion.

Econometric Analysis in FTC v. Staples | Federal Trade ...

Jul 18, 2013·The results were striking: the Staples-specific pass-through rate was only 15%, much lower than the 57% figure suggested by our first model or the 67% figure claimed by the merging firms. In other words, if Staples costs fell 10% but its rivals' costs did not change, we found, Staples …

Stapled Peptides Inhibitors: A New Window for Target Drug ...

Jan 01, 2019·Successful staples were created in both i,i + 3 and i,i + 4 linkages and a peptide with i,i + 3 stapling demonstrated a higher helicity over unstapled and lactam-stapled peptides i,i + 4. Moreover, after optimization the stapled peptide bound to a gp41-specific antibody (4E10) more effectively than the uncyclised peptide [ 50 ].

Control of Patented and Copyrighted Articles after Sale

A. B. Dick Company owned a patent covering a stencil dupli-cating machine known as the "rotary mimeograph." It sold to one Skou such a mimeograph, with a "license restriction" attached to the machine as follows: "This- machine is sold by the A. B. Dick Company with the license restriction that it may be used only with the

WO2016151478A1 - Stapled peptides and ... - Google Patents

Cyclized peptides derived from the hyaluronan binding region of RHAMM are provided. Pharmaceutical compositions and methods for using the peptides and pharmaceutical compositions are also provided. WO2016151478A1 - Stapled peptides and uses thereof - Google Patents Stapled peptides and uses thereof Download PDF Info Publication number ...

Effect of hydrocarbon stapling on the properties of α ...

Apr 17, 2012·The impact of inserting hydrocarbon staples into short α-helical antimicrobial peptides lasioglossin III and melectin (antimicrobial peptides of wild bee venom) on their biological and biophysical properties has been examined. The stapling was achieved by ring-closing olefin metathesis, either between two S-2-(4′-pentenyl) alanine residues (S 5) incorporated at i and i + 4 positions or ...

Hydrocarbon Stapled Antimicrobial Peptides. - Abstract ...

Feb 01, 2018·Staples have to connect two side chains located on the same face of the helix to stabilize peptide secondary structure (Fig. 1). In practice these two residues need to be located at i and i + 3, i + 4 (one-loop staple), i + 7 (two-loop staple), or i + 11 (three-loop staple) positions since α-helix has 3.6 residues per turn.

Protein Primary Structure

ProtScale. ProtScale allows you to compute and represent the profile produced by any amino acid scale on a selected protein.An amino acid scale is defined by a numerical value assigned to each type of amino acid. The most frequently used scales are the hydrophobicity or hydrophilicity scales and the secondary structure conformational parameters ...

EGBERT v. LIPPMANN. | Supreme Court | US Law | LII / Legal ...

11. The sixth, seventh, and fifteenth sections of the act of July 4, 1836, c. 357 (5 Stat. 117), as qualified by the seventh section of the act of March 8, 1839, c. 88 (id. 353), were in force at the date of his application.Their effect is to render letters-patent invalid if the invention which they cover was in public use, with the consent and allowance of the inventor, for more than two ...

High Cleavage Efficiency of a 2A Peptide Derived from ...

Apr 29, 2011·When expression of more than one gene is required in cells, bicistronic or multicistronic expression vectors have been used. Among various strategies employed to construct bicistronic or multicistronic vectors, an internal ribosomal entry site (IRES) has been widely used. Due to the large size and difference in expression levels between genes before and after IRES, however, a new strategy …

pMT/BiP/V5-His A, B, and C - Thermo Fisher Scientific - US

by restriction digest. Page 8, this manual 4 Select a transformant with the correct restriction pattern and sequence it to confirm that your gene is cloned in frame with the C-terminal peptide. Page 8, this manual 5 Transfect your pMT/BiP/V5-His construct into S2 cells and induce expression of the gene of interest with copper sulfate.

Longevity Biotech Granted US Patent Covering Hybridtide ...

Oct 11, 2017·PHILADELPHIA, Oct. 11, 2017 /PRNewswire/ -- Longevity Biotech, Inc. (LBT) is pleased to announce that the United States Patent and Trademark Office (USPTO) has issued U.S. Patent …

EGBERT v. LIPPMANN. | Supreme Court | US Law | LII / Legal ...

11. The sixth, seventh, and fifteenth sections of the act of July 4, 1836, c. 357 (5 Stat. 117), as qualified by the seventh section of the act of March 8, 1839, c. 88 (id. 353), were in force at the date of his application.Their effect is to render letters-patent invalid if the invention which they cover was in public use, with the consent and allowance of the inventor, for more than two ...

Econometric Analysis in FTC v. Staples | Federal Trade ...

Jul 18, 2013·The results were striking: the Staples-specific pass-through rate was only 15%, much lower than the 57% figure suggested by our first model or the 67% figure claimed by the merging firms. In other words, if Staples costs fell 10% but its rivals' costs did not change, we found, Staples …

EGBERT v. LIPPMANN. | Supreme Court | US Law | LII / Legal ...

11. The sixth, seventh, and fifteenth sections of the act of July 4, 1836, c. 357 (5 Stat. 117), as qualified by the seventh section of the act of March 8, 1839, c. 88 (id. 353), were in force at the date of his application.Their effect is to render letters-patent invalid if the invention which they cover was in public use, with the consent and allowance of the inventor, for more than two ...

Effect of hydrocarbon stapling on the properties of α ...

Apr 17, 2012·The impact of inserting hydrocarbon staples into short α-helical antimicrobial peptides lasioglossin III and melectin (antimicrobial peptides of wild bee venom) on their biological and biophysical properties has been examined. The stapling was achieved by ring-closing olefin metathesis, either between two S-2-(4′-pentenyl) alanine residues (S 5) incorporated at i and i + 4 positions or ...